Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.58 |
| ▸ | TSHR | P16473 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182389 | 1.00 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL182854 | 0.93 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL182570 | 0.93 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL183092 | 0.90 | CLK4 (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL182771 | 0.86 | PIK3CD (0.73) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL182889 | 0.82 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL182604 | 0.82 | SRC (0.51) | CLK4CYP2D6CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL182705 | 0.80 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL183209 | 0.79 | PIK3CD (0.64) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL182593 | 0.79 | PIK3CD (0.64) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | claimed |
| US-20090258882-A1 | 2,4-Substituted Quinazolines as Lipid Kinase Inhibitors | NOVARTIS AG | 2009-10-15 | — | — | US | claimed |
| CN-101490016-A | 2,4-substituted quinazolines as lipid kinase inhibitors | NOVARTIS AG (CH) | 2009-07-22 | — | — | CN | claimed |
| EP-2049502-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | Novartis AG (CH) | 2009-04-22 | — | — | EP | claimed |
| WO-2008012326-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-31 | — | — | WO | claimed |
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | disclosed |
| CN-101490016-A | 2,4-substituted quinazolines as lipid kinase inhibitors | NOVARTIS AG (CH) | 2009-07-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258882-A1 | 2,4-Substituted Quinazolines as Lipid Kinase Inhibitors | PDPK1, PI4KA, PIK3CA | PIK3CD 6/4885PIK3CA 3/4885PIK3CB 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.