Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 20/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.80 |
| ▸ | TDO2 | P48775 | 1/20 | 0.80 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL145813 | 0.93 | IDO1 (1.00) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| Epacadostat SCHEMBL30521952 | 0.89 | IDO1 (1.00) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| Epacadostat SCHEMBL19808101 | 0.89 | IDO1 (1.00) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| Epacadostat SCHEMBL145947 | 0.89 | IDO1 (1.00) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| Epacadostat SCHEMBL148867 | 0.89 | IDO1 (1.00) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL144215 | 0.87 | IDO1 (0.89) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL20702061 | 0.85 | IDO1 (0.82) | IDO1 | |
| SCHEMBL1838744 | 0.85 | IDO1 (0.72) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL20702081 | 0.85 | IDO1 (0.75) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL20702055 | 0.84 | IDO1 (0.81) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011527686-A | — | — | 2011-11-04 | — | — | JP | claimed |
| EP-2315756-A2 | 1,2,5-OXADIAZOLES AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | Incyte Corporation (US) | 2011-05-04 | — | — | EP | claimed |
| WO-2010005958-A2 | 1,2,5-OXADIAZOLES AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | INCYTE CORPORATION (US) | 2010-01-14 | — | — | WO | claimed |