Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ5 | P48544 | 3/20 | 0.67 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.60 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 4/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.42 |
| ▸ | MST1R | Q04912 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18343046 | 0.86 | KCNJ5 (0.61) | KCNJ5IRAK4JAK2JAK1JAK3 | |
| SCHEMBL18343018 | 0.83 | IRAK4 (0.59) | KCNJ5IRAK4 | |
| SCHEMBL17764645 | 0.82 | IRAK4 (0.61) | KCNJ5IRAK4JAK2JAK1JAK3 | |
| SCHEMBL18343023 | 0.81 | KCNJ5 (1.00) | KCNJ5IRAK4 | |
| SCHEMBL21958305 | 0.76 | KCNJ5 (0.50) | KCNJ5IRAK4JAK2JAK1JAK3 | |
| SCHEMBL31262468 | 0.76 | KCNJ5 (0.44) | KCNJ5IRAK4JAK2JAK1JAK3 | |
| SCHEMBL18345067 | 0.76 | IRAK4 (1.00) | KCNJ5IRAK4 | |
| SCHEMBL31262505 | 0.75 | IRAK4 (0.47) | KCNJ5IRAK4JAK2JAK1JAK3 | |
| SCHEMBL18343024 | 0.75 | KCNJ5 (1.00) | KCNJ5IRAK4 | |
| SCHEMBL26598702 | 0.74 | MKNK1 (0.52) | KCNJ5IRAK4JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3313844-B1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-08-26 | — | — | EP | disclosed |
| EP-3313844-B1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-08-26 | — | — | EP | disclosed |
| CN-108026099-B | Heteroaryl substituted aminopyridine compounds | 百时美施贵宝公司 | 2020-07-10 | — | — | CN | disclosed |
| US-10202390-B2 | Heteroaryl substituted aminopyridine compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-02-12 | — | — | US | disclosed |
| US-10202390-B2 | Heteroaryl substituted aminopyridine compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-02-12 | — | — | US | disclosed |
| US-20180179213-A1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2018-06-28 | — | — | US | disclosed |
| US-20180179213-A1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2018-06-28 | — | — | US | disclosed |
| US-20180179213-A1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2018-06-28 | — | — | US | disclosed |
| EP-3313844-A1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2018-05-02 | — | — | EP | disclosed |
| WO-2016210037-A1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202390-B2 | Heteroaryl substituted aminopyridine compounds | IRAK4, IRAK3, IRAK2 | KCNJ5 1519/4885IRAK4 1/4885JAK2 18/4885 |
| US-20180179213-A1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | IRAK4, IRAK3, IRAK2 | KCNJ5 1519/4885IRAK4 1/4885JAK2 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.