Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 12/20 | 1.00 |
| ▸ | STK3 | Q13188 | 1/20 | 0.69 |
| ▸ | EGFR | P00533 | 7/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.63 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22419816 | 0.94 | STK4 (0.90) | STK4STK3EGFRERBB2IGF1R | |
| SCHEMBL22419674 | 0.93 | STK4 (0.86) | STK4STK3EGFRERBB2 | |
| SCHEMBL22419663 | 0.91 | STK4 (1.00) | STK4STK3EGFRERBB2 | |
| SCHEMBL22419631 | 0.91 | STK4 (1.00) | STK4STK3EGFRERBB2 | |
| SCHEMBL22419673 | 0.91 | STK4 (0.84) | STK4STK3EGFRERBB2 | |
| SCHEMBL22419632 | 0.91 | STK4 (1.00) | STK4STK3EGFRERBB2 | |
| SCHEMBL22419664 | 0.91 | STK4 (0.84) | STK4STK3EGFRERBB2 | |
| SCHEMBL22419865 | 0.91 | STK4 (1.00) | STK4STK3EGFRERBB2 | |
| SCHEMBL29515043 | 0.91 | STK4 (1.00) | STK4STK3EGFRERBB2 | |
| SCHEMBL22419619 | 0.91 | STK4 (0.82) | STK4STK3EGFRERBB2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11427560-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-08-30 | — | — | US | disclosed |
| US-11427560-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-08-30 | — | — | US | disclosed |
| US-20210061784-A1 | COMPOSITION AND METHODS FOR INHIBITING MAMMALIAN STERILE 20-LIKE KINASE 1 | UNIVERSITÄT BREMEN (DE) | 2021-03-04 | — | — | US | disclosed |
| US-20210061784-A1 | COMPOSITION AND METHODS FOR INHIBITING MAMMALIAN STERILE 20-LIKE KINASE 1 | UNIVERSITÄT BREMEN (DE) | 2021-03-04 | — | — | US | disclosed |
| US-10774068-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-09-15 | — | — | US | disclosed |
| US-10774068-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-09-15 | — | — | US | disclosed |
| US-20180362497-A1 | COMPOSITION AND METHODS FOR INHIBITING MAMMALIAN STERILE 20-LIKE KINASE 1 | UNIVERSITÄT BREMEN (DE) | 2018-12-20 | — | — | US | disclosed |
| WO-2016210345-A1 | COMPOSITION AND METHODS FOR INHIBITING MAMMALIAN STERILE 20-LIKE KINASE 1 | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2016-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061784-A1 | COMPOSITION AND METHODS FOR INHIBITING MAMMALIAN STERILE 20-LIKE KINASE 1 | TESK2, TESK1, PRKACB | STK4 852/4885STK3 456/4885EGFR 3953/4885 |
| US-20180362497-A1 | COMPOSITION AND METHODS FOR INHIBITING MAMMALIAN STERILE 20-LIKE KINASE 1 | TESK2, TESK1, PRKACB | STK4 852/4885STK3 456/4885EGFR 3953/4885 |
| US-11427560-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | TESK2, TESK1, PRKACB | STK4 852/4885STK3 456/4885EGFR 3953/4885 |
| US-10774068-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | TESK2, TESK1, PRKACB | STK4 852/4885STK3 456/4885EGFR 3953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.