Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 14/20 | 0.53 |
| ▸ | CCNH | P51946 | 14/20 | 0.53 |
| ▸ | PIP4K2A | P48426 | 4/20 | 0.51 |
| ▸ | PIP4K2B | P78356 | 4/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20211532 | 0.92 | CDK7 (0.63) | CDK7CCNHPIP4K2APIP4K2BMAPK8 | |
| SCHEMBL20211533 | 0.92 | CDK7 (0.63) | CDK7CCNHPIP4K2APIP4K2BMAPK8 | |
| SCHEMBL20225382 | 0.81 | CDK7 (0.75) | CDK7CCNHPIP4K2APIP4K2BMAPK8 | |
| SCHEMBL20228953 | 0.80 | CDK7 (0.61) | CDK7CCNHPIP4K2APIP4K2BMAPK8 | |
| SCHEMBL20228952 | 0.79 | CDK7 (0.63) | CDK7CCNHPIP4K2APIP4K2BMAPK8 | |
| SCHEMBL20225389 | 0.77 | PIP4K2A (0.71) | CDK7CCNHPIP4K2APIP4K2BMAPK8 | |
| SCHEMBL18340729 | 0.76 | PIP4K2A (0.84) | CDK7CCNHPIP4K2APIP4K2BMAPK8 | |
| SCHEMBL20225395 | 0.75 | CDK7 (0.48) | CDK7CCNHPIP4K2APIP4K2BMAPK8 | |
| SCHEMBL18340702 | 0.74 | PIP4K2A (0.68) | CDK7CCNHPIP4K2APIP4K2BMAPK8 | |
| SCHEMBL18346365 | 0.74 | CDK7 (0.55) | CDK7CCNHPIP4K2APIP4K2BJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3313529-A1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES AND USES THEREOF | Dana Farber Cancer Institute, Inc. (US) | 2018-05-02 | — | — | EP | disclosed |
| WO-2016210291-A1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-12-29 | — | — | WO | disclosed |