SCHEMBL18351925

SCHEMBL18351925

NC(=O)c1cnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1ccc2c(c1)CN(S(=O)(=O)Cc1ccccc1)CC2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SYK P43405 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18351923 1.00 SYK (1.00) SYK
SCHEMBL18351844 0.91 SYK (1.00) SYK
SCHEMBL18351843 0.91 SYK (1.00) SYK
SCHEMBL18351769 0.89 SYK (1.00) SYK
SCHEMBL18351768 0.89 SYK (1.00) SYK
SCHEMBL18351929 0.88 SYK (1.00) SYK
SCHEMBL18351928 0.88 SYK (1.00) SYK
SCHEMBL18351772 0.87 SYK (1.00) SYK
SCHEMBL18351936 0.87 SYK (1.00) SYK
SCHEMBL18351773 0.87 SYK (1.00) SYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9533989-B2 Substituted pyrimidine-5-carboxamides as spleen tyrosine kinase inhibitors Ziarco Pharma Ltd. (GB) 2017-01-03 US claimed