⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28421001 | 1.00 | — | — | |
| SCHEMBL20268301 | 1.00 | — | — | |
| SCHEMBL12191280 | 0.87 | — | — | |
| SCHEMBL12800149 | 0.82 | — | — | |
| SCHEMBL4343121 | 0.81 | SCN4A (0.32) | — | |
| SCHEMBL365628 | 0.81 | SCN4A (0.32) | — | |
| SCHEMBL4207669 | 0.81 | SCN4A (0.32) | — | |
| SCHEMBL30148744 | 0.78 | — | — | |
| SCHEMBL1369530 | 0.78 | — | — | |
| SCHEMBL20288089 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111909173-B | Benzoxazepine oxazolidinone compounds and methods of use thereof | 豪夫迈·罗氏有限公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-112047960-B | Benzoxazepine oxazolidinone compounds and methods of use thereof | 豪夫迈·罗氏有限公司 | 2024-08-02 | — | — | CN | disclosed |
| CN-112062778-B | Benzoxazepine oxazolidinone compounds and methods of use thereof | 豪夫迈·罗氏有限公司 | 2024-04-19 | — | — | CN | disclosed |
| US-11760753-B2 | Benzoxazepin oxazolidinone compounds and methods of use | GENENTECH, INC. (US) | 2023-09-19 | — | — | US | disclosed |
| US-11760753-B2 | Benzoxazepin oxazolidinone compounds and methods of use | GENENTECH, INC. (US) | 2023-09-19 | — | — | US | disclosed |
| EP-4212536-A1 | BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2023-07-19 | — | — | EP | disclosed |
| EP-3851441-B1 | PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO) PROPANAMIDE | HOFFMANN LA ROCHE (CH) | 2023-06-28 | — | — | EP | disclosed |
| EP-3851441-B1 | PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO) PROPANAMIDE | HOFFMANN LA ROCHE (CH) | 2023-06-28 | — | — | EP | disclosed |
| EP-4165023-A1 | INHIBITORS OF APOL1 AND USE OF THE SAME | Vertex Pharmaceuticals Incorporated (US) | 2023-04-19 | — | — | EP | disclosed |
| CN-115867532-A | Inhibitors of APOL1 and uses thereof | 弗特克斯药品有限公司 | 2023-03-28 | — | — | CN | disclosed |
| US-20170210733-A1 | BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2017-07-27 | — | — | US | disclosed |
| US-20170210733-A1 | BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2017-07-27 | — | — | US | disclosed |
| US-9650393-B2 | Benzoxazepin oxazolidinone compounds and methods of use | GENENTECH, INC. (US) | 2017-05-16 | — | — | US | disclosed |
| US-9650393-B2 | Benzoxazepin oxazolidinone compounds and methods of use | GENENTECH, INC. (US) | 2017-05-16 | — | — | US | disclosed |
| US-9643980-B2 | Benzoxazepin oxazolidinone compounds and methods of use | GENENTECH, INC. (US) | 2017-05-09 | — | — | US | disclosed |
| US-9643980-B2 | Benzoxazepin oxazolidinone compounds and methods of use | GENENTECH, INC. (US) | 2017-05-09 | — | — | US | disclosed |
| US-20170015678-A1 | BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2017-01-19 | — | — | US | disclosed |
| US-20170015678-A1 | BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2017-01-19 | — | — | US | disclosed |
| US-20170002022-A1 | BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2017-01-05 | — | — | US | disclosed |
| US-20170002022-A1 | BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2017-01-05 | — | — | US | disclosed |