Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18360687 | 0.82 | MAPK1 (0.40) | MAPK1 | |
| SCHEMBL18360678 | 0.81 | — | — | |
| SCHEMBL15084381 | 0.80 | — | — | |
| SCHEMBL18360581 | 0.76 | — | — | |
| SCHEMBL18360724 | 0.76 | PDE1C (0.44) | KDM2B | |
| SCHEMBL18360680 | 0.76 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL18360589 | 0.76 | — | — | |
| SCHEMBL18360605 | 0.75 | MAPK1 (0.46) | MAPK1 | |
| SCHEMBL18360587 | 0.74 | MAPK1 (0.46) | MAPK1 | |
| SCHEMBL15065273 | 0.73 | MAPK1 (0.55) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2615916-B1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2017-01-04 | — | — | EP | disclosed |