Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15065335 | 1.00 | MAPK1 (0.59) | MAPK1 | |
| SCHEMBL15065460 | 0.93 | MAPK1 (0.52) | MAPK1 | |
| SCHEMBL15065273 | 0.87 | MAPK1 (0.55) | MAPK1 | |
| SCHEMBL15065264 | 0.86 | — | — | |
| SCHEMBL807498 | 0.86 | — | — | |
| SCHEMBL15065380 | 0.85 | MAPK1 (0.53) | MAPK1 | |
| SCHEMBL10211864 | 0.85 | — | — | |
| SCHEMBL15065337 | 0.85 | — | — | |
| SCHEMBL15065403 | 0.84 | — | — | |
| SCHEMBL15065255 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2615916-B1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2017-01-04 | — | — | EP | disclosed |