Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.61 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.50 |
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | JAK1 | P23458 | 3/20 | 0.48 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | STAT6 | P42226 | 2/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL736746 | 0.88 | SYK (0.61) | SYKMAPK8JAK2JAK1JAK3 | |
| SCHEMBL736747 | 0.88 | SYK (0.61) | SYKMAPK8JAK2JAK1JAK3 | |
| SCHEMBL735005 | 0.87 | SYK (0.61) | SYK | |
| SCHEMBL735006 | 0.87 | SYK (0.61) | SYK | |
| SCHEMBL1839202 | 0.87 | SYK (0.59) | SYKMAPK8JAK2JAK1JAK3 | |
| SCHEMBL20354265 | 0.86 | SYK (0.58) | SYKMAPK8JAK2JAK1JAK3 | |
| SCHEMBL735474 | 0.83 | SYK (0.66) | SYKMAPK8JAK2JAK1JAK3 | |
| SCHEMBL736801 | 0.82 | SYK (0.65) | SYKMAPK8JAK3STAT6 | |
| SCHEMBL14862745 | 0.80 | SYK (0.66) | SYKMAPK8JAK2JAK1JAK3 | |
| SCHEMBL14862571 | 0.77 | SYK (0.50) | SYKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321283-A1 | 2, 6-DIAMINO-PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2009145856-A1 | 2, 6-DIAMINO-PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-12-03 | — | — | WO | disclosed |