Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.60 |
| ▸ | JAK2 | O60674 | 8/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 4/20 | 0.49 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | BRD2 | P25440 | 1/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377048 | 0.92 | EGFR (0.61) | BRD4JAK2EGFRFGFR2CDK2 | |
| SCHEMBL18377033 | 0.90 | JAK2 (0.58) | BRD4JAK2FGFR1KDREGFR | |
| SCHEMBL18376722 | 0.85 | JAK2 (0.60) | BRD4JAK2FGFR1KDREGFR | |
| SCHEMBL29371867 | 0.85 | JAK2 (0.60) | BRD4JAK2FGFR1KDREGFR | |
| SCHEMBL18376729 | 0.85 | JAK2 (0.53) | BRD4JAK2FGFR1KDREGFR | |
| SCHEMBL18376724 | 0.85 | JAK2 (0.53) | BRD4JAK2FGFR1KDREGFR | |
| SCHEMBL29368444 | 0.85 | JAK2 (0.53) | BRD4JAK2FGFR1KDREGFR | |
| SCHEMBL18377035 | 0.84 | BRD4 (0.66) | BRD4JAK2JAK1JAK3BRD2 | |
| SCHEMBL29368267 | 0.84 | BRD4 (0.66) | BRD4JAK2JAK1JAK3BRD2 | |
| SCHEMBL18376225 | 0.84 | JAK2 (0.59) | BRD4JAK2FGFR1KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |