Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.57 |
| ▸ | BRD4 | O60885 | 5/20 | 0.57 |
| ▸ | JAK3 | P52333 | 12/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 10/20 | 0.55 |
| ▸ | JAK1 | P23458 | 3/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30859687 | 1.00 | JAK2 (0.57) | JAK2BRD4JAK3PTK2JAK1 | |
| SCHEMBL28696326 | 0.90 | JAK2 (0.67) | JAK2BRD4JAK3PTK2JAK1 | |
| SCHEMBL29371808 | 0.89 | JAK2 (0.58) | JAK2BRD4JAK3PTK2JAK1 | |
| SCHEMBL18377030 | 0.89 | JAK2 (0.58) | JAK2BRD4JAK3PTK2JAK1 | |
| SCHEMBL18376242 | 0.87 | JAK2 (0.56) | JAK2BRD4JAK3PTK2JAK1 | |
| SCHEMBL29371785 | 0.87 | JAK2 (0.56) | JAK2BRD4JAK3PTK2JAK1 | |
| SCHEMBL18376247 | 0.86 | BRD4 (0.60) | JAK2BRD4JAK3PTK2JAK1 | |
| SCHEMBL18376225 | 0.86 | JAK2 (0.59) | JAK2BRD4JAK3PTK2JAK1 | |
| SCHEMBL18376738 | 0.86 | JAK2 (0.64) | JAK2BRD4JAK3PTK2JAK1 | |
| SCHEMBL18376589 | 0.85 | JAK2 (0.58) | JAK2BRD4JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |