Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.54 |
| ▸ | JUN | P05412 | 5/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29205095 | 0.95 | MAPK10 (0.55) | TTKMAPK10JUNMAPK8KDM4E | |
| SCHEMBL30859690 | 0.95 | MAPK10 (0.55) | TTKMAPK10JUNMAPK8KDM4E | |
| SCHEMBL18376760 | 0.90 | TTK (0.66) | TTKMAPK10JUNMAPK8CSF1R | |
| SCHEMBL29848408 | 0.88 | MAPK10 (0.66) | TTKMAPK10JUNMAPK8DGAT1 | |
| SCHEMBL16514447 | 0.88 | MAPK10 (0.66) | TTKMAPK10JUNMAPK8DGAT1 | |
| SCHEMBL16514209 | 0.87 | MAPK10 (0.49) | TTKMAPK10JUNMAPK8CSF1R | |
| SCHEMBL16514195 | 0.87 | MAPK10 (0.50) | TTKMAPK10JUNMAPK8NPC1 | |
| SCHEMBL1632167 | 0.86 | MAPK10 (0.57) | TTKMAPK10JUNMAPK8MTOR | |
| SCHEMBL18376252 | 0.85 | TTK (0.65) | TTKMAPK10JUNMAPK8NPC1 | |
| SCHEMBL30859695 | 0.85 | TTK (0.65) | TTKMAPK10JUNMAPK8NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |