Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | JAK3 | P52333 | 2/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | JUN | P05412 | 4/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.50 |
| ▸ | TTK | P33981 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | UBE2N | P61088 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377042 | 0.92 | BRAF (0.55) | JAK2JAK3PTK2SRCKDR | |
| SCHEMBL29370829 | 0.92 | BRAF (0.55) | JAK2JAK3PTK2SRCKDR | |
| SCHEMBL16513615 | 0.91 | MAPK10 (0.59) | JAK2JAK3PTK2SRCMAPK10 | |
| SCHEMBL29371097 | 0.87 | SRC (0.53) | JAK2JAK3PTK2SRCKDR | |
| SCHEMBL18376823 | 0.87 | SRC (0.53) | JAK2JAK3PTK2SRCKDR | |
| SCHEMBL16514540 | 0.87 | MAPK10 (0.55) | JAK2JAK3PTK2SRCMAPK10 | |
| SCHEMBL29847665 | 0.87 | MAPK10 (0.55) | JAK2JAK3PTK2SRCMAPK10 | |
| SCHEMBL16514195 | 0.87 | MAPK10 (0.50) | JAK2JAK3PTK2SRCMAPK10 | |
| SCHEMBL29371925 | 0.87 | BRAF (0.60) | JAK2JAK3PTK2SRCKDR | |
| SCHEMBL18377066 | 0.87 | BRAF (0.60) | JAK2JAK3PTK2SRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |