Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 8/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 8/20 | 0.42 |
| ▸ | BTK | Q06187 | 7/20 | 0.42 |
| ▸ | LCK | P06239 | 6/20 | 0.42 |
| ▸ | ITK | Q08881 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | HCK | P08631 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14706404 | 0.94 | SRC (0.48) | SRCHDAC1CYP1A2MEN1MAPK1 | |
| SCHEMBL18380746 | 0.92 | SRC (0.45) | SRCHDAC1CYP1A2MEN1MAPK1 | |
| SCHEMBL18380716 | 0.91 | SRC (0.48) | SRCHDAC1CYP1A2MEN1MAPK1 | |
| SCHEMBL18380721 | 0.90 | SRC (0.48) | SRCHDAC1CYP1A2MEN1MAPK1 | |
| SCHEMBL18380720 | 0.88 | SRC (0.47) | SRCHDAC1CYP1A2MEN1MAPK1 | |
| SCHEMBL14693592 | 0.87 | SRC (0.55) | SRCHDAC1CYP1A2MEN1MAPK1 | |
| SCHEMBL14693595 | 0.87 | SRC (0.55) | SRCHDAC1CYP1A2MEN1MAPK1 | |
| SCHEMBL14706417 | 0.87 | SRC (0.42) | SRCEGFRBTKLCKITK | |
| SCHEMBL14706423 | 0.86 | SRC (0.45) | SRCHDAC1CYP1A2MEN1MAPK1 | |
| SCHEMBL14693569 | 0.86 | SRC (0.54) | SRCHDAC1CYP1A2MEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9546172-B2 | Pyrazolo[3,4-d]pyrimidine and pyrazolo[2,3-d]pyrimidine compounds as kinase inhibitors | PHARMACYCLICS LLC (US) | 2017-01-17 | — | — | US | disclosed |
| US-9546172-B2 | Pyrazolo[3,4-d]pyrimidine and pyrazolo[2,3-d]pyrimidine compounds as kinase inhibitors | PHARMACYCLICS LLC (US) | 2017-01-17 | — | — | US | disclosed |