Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 15/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 15/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 12/20 | 0.60 |
| ▸ | CDK9 | P50750 | 12/20 | 0.60 |
| ▸ | CDK2 | P24941 | 12/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 11/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 6/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.48 |
| ▸ | CDK1 | P06493 | 4/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.48 |
| ▸ | PRKACA | P17612 | 4/20 | 0.48 |
| ▸ | PRKACG | P22612 | 4/20 | 0.48 |
| ▸ | PRKACB | P22694 | 4/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13521485 | 0.96 | CDK5 (0.58) | CDK5CDK5R1CCNT1CDK9CDK2 | |
| SCHEMBL2984404 | 0.88 | CDK5 (0.64) | CDK5CDK5R1CCNT1CDK9CDK2 | |
| SCHEMBL13521496 | 0.87 | CDK5 (0.65) | CDK5CDK5R1CCNT1CDK9CDK2 | |
| SCHEMBL2999928 | 0.87 | CDK5 (0.63) | CDK5CDK5R1CCNT1CDK9CDK2 | |
| SCHEMBL2989519 | 0.86 | CDK5 (0.61) | CDK5CDK5R1CCNT1CDK9CDK2 | |
| SCHEMBL2988085 | 0.85 | CDK5 (0.67) | CDK5CDK5R1CCNT1CDK9CDK2 | |
| SCHEMBL2991132 | 0.85 | CDK5 (0.58) | CDK5CDK5R1CCNT1CDK9CDK2 | |
| SCHEMBL1841178 | 0.85 | CDK5 (0.57) | CDK5CDK5R1CCNT1CDK9CDK2 | |
| SCHEMBL12355043 | 0.83 | CDK5 (0.67) | CDK5CDK5R1CCNT1CDK9CDK2 | |
| SCHEMBL2238419 | 0.82 | CDK5 (0.69) | CDK5CDK5R1CCNT1CDK9CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011526931-A | — | — | 2011-10-20 | — | — | JP | claimed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | claimed |
| EP-2320895-A2 | CDK MODULATORS | Exelixis, Inc. (US) | 2011-05-18 | — | — | EP | claimed |
| WO-2010003133-A2 | CDK MODULATORS | EXELIXIS INC. (US) | 2010-01-07 | — | — | WO | claimed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| WO-2010003133-A2 | CDK MODULATORS | EXELIXIS INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | CDK3, CDK1, CDKL1 | CDK5 24/4885CDK5R1 41/4885CCNT1 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.