Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 11/20 | 0.57 |
| ▸ | CDK5R1 | Q15078 | 11/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.57 |
| ▸ | CDK9 | P50750 | 9/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.57 |
| ▸ | CDK2 | P24941 | 8/20 | 0.57 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.56 |
| ▸ | CDC42BPB | Q9Y5S2 | 9/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.52 |
| ▸ | CLK1 | P49759 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1838236 | 0.92 | ROCK1 (0.54) | CDK5CDK5R1CCNT1CDK9CCNA2 | |
| SCHEMBL2236999 | 0.84 | ROCK1 (0.73) | CDK5CDK5R1CCNT1CDK9CCNA2 | |
| SCHEMBL1837639 | 0.84 | ROCK1 (0.60) | CDK5CDK5R1CCNT1CDK9CCNA2 | |
| SCHEMBL1834620 | 0.84 | ROCK1 (0.59) | CDK5CDK5R1CCNT1CDK9CCNA2 | |
| SCHEMBL1839716 | 0.83 | ROCK1 (0.75) | CDK5CDK5R1CCNT1CDK9CCNA2 | |
| SCHEMBL1842497 | 0.83 | ROCK1 (0.75) | CDK5CDK5R1CCNT1CDK9CCNA2 | |
| SCHEMBL1841701 | 0.83 | CDK5 (0.54) | CDK5CDK5R1CCNT1CDK9CCNA2 | |
| SCHEMBL1841314 | 0.82 | CDK2 (0.58) | CDK5CDK5R1CCNT1CDK9CCNA2 | |
| SCHEMBL1839267 | 0.82 | CDK2 (0.58) | CDK5CDK5R1CCNT1CDK9CCNA2 | |
| SCHEMBL1839927 | 0.82 | CDK2 (0.58) | CDK5CDK5R1CCNT1CDK9CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011526931-A | — | — | 2011-10-20 | — | — | JP | claimed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | claimed |
| CN-102143746-A | CDK modulators | EXELIXIS INC | 2011-08-03 | — | — | CN | claimed |
| EP-2320895-A2 | CDK MODULATORS | Exelixis, Inc. (US) | 2011-05-18 | — | — | EP | claimed |
| WO-2010003133-A2 | CDK MODULATORS | EXELIXIS INC. (US) | 2010-01-07 | — | — | WO | claimed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | CDK3, CDK1, CDKL1 | CDK5 24/4885CDK5R1 41/4885CCNT1 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.