Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.47 |
| ▸ | JAK2 | O60674 | 6/20 | 0.47 |
| ▸ | JAK1 | P23458 | 5/20 | 0.47 |
| ▸ | JAK3 | P52333 | 5/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 4/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 3/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18409345 | 0.83 | JAK2 (0.50) | TYK2JAK2JAK1JAK3MEN1 | |
| SCHEMBL18398368 | 0.82 | JAK2 (0.45) | TYK2JAK2JAK1JAK3PIK3C3 | |
| SCHEMBL18398230 | 0.81 | TYK2 (0.56) | TYK2JAK2JAK1JAK3KDM4E | |
| SCHEMBL18398479 | 0.81 | JAK2 (0.52) | TYK2JAK2JAK1JAK3MAP4K1 | |
| SCHEMBL18409158 | 0.81 | TYK2 (0.58) | TYK2JAK2JAK1JAK3GSK3B | |
| SCHEMBL18409324 | 0.80 | JAK2 (0.59) | TYK2JAK2JAK1JAK3PIK3C3 | |
| SCHEMBL18409104 | 0.80 | JAK2 (0.43) | TYK2JAK2JAK1JAK3PIK3C3 | |
| SCHEMBL18398518 | 0.79 | TYK2 (0.43) | TYK2JAK2JAK1JAK3GSK3B | |
| SCHEMBL18398598 | 0.79 | TYK2 (0.47) | TYK2JAK2JAK1JAK3GSK3B | |
| SCHEMBL18398420 | 0.79 | TYK2 (0.42) | TYK2JAK2JAK1JAK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |