Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.49 |
| ▸ | JAK1 | P23458 | 8/20 | 0.49 |
| ▸ | TYK2 | P29597 | 8/20 | 0.49 |
| ▸ | JAK3 | P52333 | 8/20 | 0.49 |
| ▸ | CTSS | P25774 | 4/20 | 0.32 |
| ▸ | CTSK | P43235 | 4/20 | 0.32 |
| ▸ | CTSV | O60911 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSH | P09668 | 1/20 | 0.31 |
| ▸ | CASP4 | P49662 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | CTSZ | Q9UBR2 | 1/20 | 0.31 |
| ▸ | KLK4 | Q9Y5K2 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18398396 | 0.87 | JAK1 (0.44) | JAK2JAK1TYK2JAK3CTSS | |
| SCHEMBL18398421 | 0.86 | JAK2 (0.35) | JAK2JAK1TYK2JAK3ABCB11 | |
| SCHEMBL18398568 | 0.86 | JAK2 (0.39) | JAK2JAK1TYK2JAK3MAP2K2 | |
| SCHEMBL18409286 | 0.84 | JAK2 (0.47) | JAK2JAK1TYK2JAK3CTSS | |
| SCHEMBL16923302 | 0.83 | JAK2 (0.45) | JAK2JAK1TYK2JAK3CTSS | |
| SCHEMBL18398275 | 0.81 | JAK2 (0.39) | JAK2JAK1TYK2JAK3CTSS | |
| SCHEMBL15184329 | 0.81 | JAK2 (0.43) | JAK2JAK1TYK2JAK3MAP2K1 | |
| SCHEMBL18409285 | 0.80 | TYK2 (0.62) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18398229 | 0.78 | JAK2 (0.51) | JAK2JAK1TYK2JAK3CTSS | |
| SCHEMBL18398169 | 0.78 | JAK2 (0.62) | JAK2JAK1TYK2JAK3CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |