Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexrazoxane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A known ✓ | P11388 | 3/20 | 1.00 |
| ▸ | TOP2B known ✓ | Q02880 | 3/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexrazoxane SCHEMBL1586271 | 1.00 | TOP2A (1.00) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| Razoxane SCHEMBL27174203 | 0.98 | TOP2A (0.96) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| Razoxane SCHEMBL27748349 | 0.98 | TOP2A (0.96) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| Dexrazoxane SCHEMBL18188 | 0.98 | TOP2A (0.96) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| Dexrazoxane SCHEMBL18189 | 0.96 | TOP2A (0.93) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| Dexrazoxane SCHEMBL27918475 | 0.96 | TOP2A (0.93) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| Dexrazoxane SCHEMBL28086609 | 0.94 | TOP2A (0.89) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| Dexrazoxane SCHEMBL5488431 | 0.91 | TOP2A (0.83) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| Dexrazoxane SCHEMBL5295434 | 0.91 | TOP2A (0.83) | TOP2ATOP2BPTGS1LMNAALDH1A1 | |
| SCHEMBL21473070 | 0.90 | TOP2A (0.81) | TOP2ATOP2BPTGS1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 35956 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075696-A | Application of MSR1 inhibitor in preparation of anti-tumor immunopotentiator | — | 2026-05-26 | — | — | CN | claimed |
| CN-117837492-B | Breeding method of cabbage type rape radish cytoplasmic restorer line independent of restoring source | 成都市农林科学院 | 2026-05-19 | — | — | CN | claimed |
| EP-4739300-A1 | MODULATORS OF IRON METABOLISM FOR TREATING CONDITIONS ASSOCIATED WITH CONE PHOTORECEPTOR DEGENERATION | SORBONNE UNIVERSITE (FR) | 2026-05-13 | — | — | EP | claimed |
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-04-30 | — | — | US | claimed |
| US-20260108476-A1 | 2,4 DNP and Prodrugs Thereof for Treatment of Cancer | MITOCHON PHARMACEUTICALS, INC. (US) | 2026-04-23 | — | — | US | claimed |
| EP-3746081-B1 | PDE1 INHIBITORS FOR USE TO TREAT CARDIAC FAILURE AND CARDIOTOXICITY | INTRA CELLULAR THERAPIES INC (US) | 2026-04-01 | — | — | EP | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-12577255-B2 | MDM2-based modulators of proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2026-03-17 | — | — | US | claimed |
| EP-4704832-A2 | BIFUNCTIONAL SMALL MOLECULES TO TARGET THE SELECTIVE DEGRADATION OF CIRCULATING PROTEINS | Biohaven Therapeutics Ltd. (VG) | 2026-03-11 | — | — | EP | claimed |
| US-12539966-B2 | Fixed drone visualization in security systems | TYCO FIRE & SECURITY GMBH (CH) | 2026-02-03 | — | — | US | claimed |
| EP-0954283-A2 | FORMULATION AND METHOD FOR TREATING NEOPLASMS BY INHALATION | BATTELLE MEMORIAL INSTITUTE (US) | 1999-11-10 | — | — | EP | claimed |
| EP-0611369-B1 | PROCESS FOR PREPARING (S) (+)-4,4'-(1-METHYL-1,2-ETHANEDIYL)-BIS(2,6-PIPERAZINEDIONE) | EUROCETUS BV (NL) | 1999-07-28 | — | — | EP | claimed |
| WO-1998029110-A2 | FORMULATION AND METHOD FOR TREATING NEOPLASMS BY INHALATION | BATTELLE MEMORIAL INSTITUTE (US) | 1998-07-09 | — | — | WO | claimed |
| WO-1998029086-A1 | REDUCTION OF HAIR GROWTH | HANDELMAN, JOSEPH, H. (US) | 1998-07-09 | — | — | WO | claimed |
| EP-0330381-B1 | Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes | ERBAMONT INC (US) | 1995-05-24 | — | — | EP | claimed |
| WO-1993021938-A1 | METHODS FOR TREATING CANCER USING HIGH-DOSE EPIRUBICIN | ADRIA LABORATORIES (US) | 1993-11-11 | — | — | WO | claimed |
| EP-0284594-B1 | PROCESS FOR PREPARING (S) (+)-4,4'-(1-METHYL-1,2-ETHANEDIYL)-BIS (2,6-PIPERAZINEDIONE) | ERBAMONT, INC. (US) | 1993-01-13 | — | — | EP | claimed |
| US-4963679-A | Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes | ERBAMONT, INC. (US) | 1990-10-16 | — | — | US | claimed |
| EP-0330381-A1 | Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes | ERBAMONT, INC. (US) | 1989-08-30 | — | — | EP | claimed |
| US-4764614-A | CYCLIZATION OF PROPYLENEDIAMINE TETRAACETIC TETRAAMIDE | MONSANTO COMPANY (US) | 1988-08-16 | — | — | US | claimed |