⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493211 | 0.80 | FFAR4 (0.34) | — | |
| SCHEMBL14370124 | 0.77 | — | — | |
| SCHEMBL962421 | 0.76 | — | — | |
| SCHEMBL76463 | 0.76 | — | — | |
| SCHEMBL1834515 | 0.74 | FFAR1 (0.32) | — | |
| SCHEMBL20399500 | 0.74 | — | — | |
| SCHEMBL832439 | 0.74 | — | — | |
| SCHEMBL6379288 | 0.73 | — | — | |
| SCHEMBL17125247 | 0.73 | FFAR1 (0.31) | — | |
| SCHEMBL8095966 | 0.72 | MAPT (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024048714-A1 | METHOD FOR PRODUCING 6-(4,4-DIMETHYLCYCLOHEXYL)-4-[(1,1-DIOXO-1λ6-THIOMORPHOLIN-4-YL)METHYL]-2-METHYLTHIENO[2,3-D]PYRIMIDINE OR SALT THEREOF | アステラス製薬株式会社 | 2024-03-07 | — | — | WO | disclosed |
| EP-3059239-B1 | SULFUR-CONTAINING BICYCLIC COMPOUND | ASTELLAS PHARMA INC (JP) | 2018-06-27 | — | — | EP | disclosed |
| EP-3059239-B1 | SULFUR-CONTAINING BICYCLIC COMPOUND | ASTELLAS PHARMA INC (JP) | 2018-06-27 | — | — | EP | disclosed |
| CN-105636965-B | The ring type compound of sulfur-bearing two | 安斯泰来制药株式会社 | 2017-11-24 | — | — | CN | disclosed |
| US-9642852-B2 | Sulfur-containing bicyclic compound | ASTELLAS PHARMA INC. (JP) | 2017-05-09 | — | — | US | disclosed |
| US-9642852-B2 | Sulfur-containing bicyclic compound | ASTELLAS PHARMA INC. (JP) | 2017-05-09 | — | — | US | disclosed |
| US-9642852-B2 | Sulfur-containing bicyclic compound | ASTELLAS PHARMA INC. (JP) | 2017-05-09 | — | — | US | disclosed |
| EP-3059239-A1 | SULFUR-CONTAINING BICYCLIC COMPOUND | Astellas Pharma Inc. (JP) | 2016-08-24 | — | — | EP | disclosed |
| EP-3059239-A1 | SULFUR-CONTAINING BICYCLIC COMPOUND | Astellas Pharma Inc. (JP) | 2016-08-24 | — | — | EP | disclosed |
| CN-105636965-A | Sulfur-containing bicyclic compound | ASTELLAS PHARMA INC | 2016-06-01 | — | — | CN | disclosed |
| US-9051339-B2 | Sulfur-containing bicyclic compound | ASTELLAS PHARMA INC. (JP) | 2015-06-09 | — | — | US | disclosed |
| US-9051339-B2 | Sulfur-containing bicyclic compound | ASTELLAS PHARMA INC. (JP) | 2015-06-09 | — | — | US | disclosed |
| US-20150111876-A1 | SULFUR-CONTAINING BICYCLIC COMPOUND | ASTELLAS PHARMA INC. (JP) | 2015-04-23 | — | — | US | disclosed |
| US-20150111876-A1 | SULFUR-CONTAINING BICYCLIC COMPOUND | ASTELLAS PHARMA INC. (JP) | 2015-04-23 | — | — | US | disclosed |
| US-20150111876-A1 | SULFUR-CONTAINING BICYCLIC COMPOUND | ASTELLAS PHARMA INC. (JP) | 2015-04-23 | — | — | US | disclosed |
| EP-2320738-A1 | SUBSTITUTED AMINOTHIAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE | TransTech Pharma, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010025142-A1 | SUBSTITUTED AMINOTHIAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE | TRANSTECH PHARMA, INC. (US) | 2010-03-04 | — | — | WO | disclosed |
| US-20080045533-A1 | Novel cyclohexyl sulphones | CHURCHER IAN | 2008-02-21 | — | — | US | disclosed |
| US-7304094-B2 | Alzheimer's disease, modulate the processing of amyloid precursor protein by gamma-secretase | MERCK SHARP + DOHME | 2007-12-04 | — | — | US | disclosed |
| US-7276637-B2 | Synthesis of cyclohexanone derivatives | MERCK SHARP & DOHME LIMITED (GB) | 2007-10-02 | — | — | US | disclosed |