SCHEMBL18407484

SCHEMBL18407484

CCC(CC)n1c(C(=N)NC)cc2cnc(Nc3ccc(N4CCNCC4)cc3)nc21

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 17/20 0.54
CCND1 P24385 16/20 0.54
CDK2 P24941 10/20 0.54
CCNA2 P20248 9/20 0.54
CCND2 P30279 5/20 0.51
CCND3 P30281 5/20 0.51
FGFR1 P11362 8/20 0.50
FGFR2 P21802 8/20 0.50
FGFR4 P22455 8/20 0.50
FGFR3 P22607 8/20 0.50
CDK6 Q00534 1/20 0.48
STAT6 P42226 1/20 0.47
CDK1 P06493 1/20 0.47
CCNB1 P14635 1/20 0.47
CCNE1 P24864 1/20 0.47
MAPK8 P45983 1/20 0.46
MAPK9 P45984 1/20 0.46
MAPK10 P53779 1/20 0.46
CCNA1 P78396 1/20 0.46
NUAK1 O60285 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11977151 0.90 CDK4 (0.57) CDK4CCND1CDK2CCNA2CCND2
SCHEMBL4197914 0.88 CDK4 (0.58) CDK4CCND1CDK2CCNA2CCND2
SCHEMBL4346927 0.85 CDK4 (0.68) CDK4CCND1CDK2CCNA2CCND2
SCHEMBL18407408 0.85 CDK4 (0.57) CDK4CCND1CDK2CCNA2CCND2
SCHEMBL11977141 0.84 CDK4 (0.58) CDK4CCND1CDK2CCNA2CCND2
SCHEMBL4200717 0.84 CDK4 (0.61) CDK4CCND1CDK2CCNA2CCND2
SCHEMBL18407386 0.83 CDK4 (0.51) CDK4CCND1CDK2CCNA2CCND2
SCHEMBL11977150 0.83 CDK4 (0.57) CDK4CCND1CDK2CCNA2CCND2
SCHEMBL11977153 0.83 CDK4 (0.54) CDK4CCND1CDK2CCNA2CCND2
SCHEMBL11977148 0.83 CDK4 (0.54) CDK4CCND1CDK2CCNA2CCND2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2029145-B1 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES NOVARTIS AG (CH) 2017-01-25 EP disclosed