Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.40 |
| ▸ | JAK1 | P23458 | 6/20 | 0.40 |
| ▸ | TYK2 | P29597 | 6/20 | 0.40 |
| ▸ | JAK3 | P52333 | 6/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18398547 | 0.86 | JAK2 (0.43) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18398222 | 0.85 | JAK2 (0.35) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL18398431 | 0.83 | JAK2 (0.46) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18398441 | 0.82 | JAK2 (0.43) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL18398569 | 0.81 | JAK2 (0.34) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18398169 | 0.79 | JAK2 (0.62) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18398516 | 0.79 | JAK2 (0.43) | JAK2JAK1TYK2JAK3HRH4 | |
| SCHEMBL18398599 | 0.78 | JAK2 (0.44) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18398410 | 0.77 | JAK2 (0.48) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL18398404 | 0.77 | JAK2 (0.41) | JAK2JAK1TYK2JAK3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |