Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methylpyrrolidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.77 |
| ▸ | BRD2 | P25440 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | INMT | O95050 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylpyrrolidone SCHEMBL8411368 | 0.94 | BRD4 (0.68) | BRD4BRD2LMNACA12CA1 | |
| Methylpyrrolidone SCHEMBL7117712 | 0.91 | BRD4 (0.71) | BRD4BRD2LMNACA12CA1 | |
| Methylpyrrolidone SCHEMBL3802011 | 0.91 | BRD4 (0.77) | BRD4BRD2LMNACA12CA1 | |
| Methylpyrrolidone SCHEMBL27475593 | 0.91 | BRD4 (0.77) | BRD4BRD2LMNACA12CA1 | |
| Methylpyrrolidone SCHEMBL10902634 | 0.91 | BRD4 (0.85) | BRD4BRD2LMNACA12CA1 | |
| Methylpyrrolidone SCHEMBL9815876 | 0.89 | BRD4 (0.74) | BRD4BRD2LMNACA12CA1 | |
| Methylpyrrolidone SCHEMBL1368701 | 0.88 | — | — | |
| Methylpyrrolidone SCHEMBL8055062 | 0.88 | BRD4 (1.00) | BRD4BRD2LMNACA12CA1 | |
| Methylpyrrolidone SCHEMBL5423326 | 0.88 | — | — | |
| Methylpyrrolidone SCHEMBL487 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116130602-A | Negative electrode plate, preparation method thereof and battery | 湖北亿纬动力有限公司 | 2023-05-16 | — | — | CN | claimed |
| CN-112108133-B | Surface-modified polyimide aerogel and preparation method and application thereof | 济南市畜产品质量安全监测中心 | 2023-03-17 | — | — | CN | claimed |
| CN-111564631-B | Lithium ion battery positive glue solution and preparation method thereof | 惠州市恒泰科技股份有限公司 | 2021-08-31 | — | — | CN | claimed |
| CN-111564631-A | Lithium ion battery positive glue solution and preparation method thereof | 惠州市恒泰科技股份有限公司 | 2020-08-21 | — | — | CN | claimed |
| CN-107936247-B | Insoluble salt and polyimide aerogel composite photocatalyst and preparation method thereof | 山东省科学院新材料研究所 | 2020-04-17 | — | — | CN | claimed |
| CN-110951107-A | Controllable preparation of PI aerogel material and photocatalytic reduction of CO2In (1) | 山东省科学院新材料研究所 | 2020-04-03 | — | — | CN | claimed |
| CN-107151319-B | A kind of multiple stimulation response crosslinking polymer nano-hydrogel, preparation method and application | 哈尔滨工业大学无锡新材料研究院 | 2019-02-19 | — | — | CN | claimed |
| CN-107151319-A | A kind of multiple stimulation response crosslinking polymer nano-hydrogel, its preparation method and application | 哈尔滨工业大学无锡新材料研究院 | 2017-09-12 | — | — | CN | claimed |
| CN-104492278-B | High-stability high-permeability compact ceramic oxygen-permeation membrane and preparation method thereof | 景德镇陶瓷大学 | 2017-04-26 | — | — | CN | claimed |
| EP-1973908-A2 | PROCESSES AND INTERMEDIATES USEFUL FOR PREPARING INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2008-10-01 | — | — | EP | claimed |
| WO-2007076005-A2 | PROCESSES AND INTERMEDIATES USEFUL FOR PREPARING INTEGRASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2007-07-05 | — | — | WO | claimed |
| JP-4316607-A | — | — | None | — | — | JP | disclosed |
| CN-115558125-B | Composite solvent and preparation method and application thereof | 海卓动力(北京)能源科技有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-113387351-B | Preparation process for preparing three-dimensional porous graphene at low cost | 辽宁聚泰鑫新材料研究有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-113387351-A | Preparation process for preparing three-dimensional porous graphene at low cost | 辽宁聚泰鑫新材料研究有限公司 | 2021-09-14 | — | — | CN | disclosed |
| WO-1993018102-A1 | CLEANER COMPOSITIONS | TRANSCONTINENTAL MARKETING GROUP INC. (US) | 1993-09-16 | — | — | WO | disclosed |
| JP-H04316607-A | PRODUCTION OF POROUS SOLID YARN | NOK CORP | 1992-11-09 | — | — | JP | disclosed |
| US-5120799-A | POLYMERIC COMPOUNDS HAVING PENDANT SULPHONATO GROUPS AND METHOD OF PRODUCING THE POLYMERIC COMPOUNDS | E. I. DU PONT DE NEMOURS AND COMPANY (INC.) (US) | 1992-06-09 | — | — | US | disclosed |
| US-4574129-A | Topical nonsteroidal anti-inflammatory methods | BRISTOL-MYERS COMPANY (US) | 1986-03-04 | — | — | US | disclosed |
| US-4540581-A | ADRENERGIC BLOCKING AGENTS | BRISTOL-MYERS COMPANY (US) | 1985-09-10 | — | — | US | disclosed |