Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2323942 | 1.00 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL1290635 | 0.93 | SMN1; SMN2 (0.70) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL1437263 | 0.92 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL14539329 | 0.89 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL25275303 | 0.88 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL30917595 | 0.88 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL31449857 | 0.87 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL6062459 | 0.85 | SMN1; SMN2 (0.70) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL21497616 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL31460273 | 0.83 | SMN1; SMN2 (0.76) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590978-B1 | CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY | FOB SYNTHESIS INC (US) | 2017-09-20 | — | — | EP | disclosed |
| US-20150306071-A1 | Carbapenem Antibacterials with Gram-Negative Activity | CHOI, WOO-BAEG, DR. | 2015-10-29 | — | — | US | disclosed |
| US-9149461-B2 | Carbapenem antibacterials with gram-negative activity | FOB SYNTHESIS, INC. (US) | 2015-10-06 | — | — | US | disclosed |
| US-20130172313-A1 | Carbapenem Antibacterials with Gram-Negative Activity | FOB SYNTHESIS, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| WO-2011160020-A2 | CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY | FOB SYNTHESIS (US) | 2011-12-22 | — | — | WO | disclosed |
| EP-1192136-B1 | OLIGOMERS AND POLYMERS OF CYCLIC IMINO CARBOXYLIC ACIDS | WISCONSIN ALUMNI RES FOUND (US) | 2011-05-18 | — | — | EP | disclosed |
| US-7304165-B2 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304165-B2 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304165-B2 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-12-04 | — | — | US | disclosed |
| US-6914048-B2 | Method for delivery of molecules to intracellular targets | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2005-07-05 | — | — | US | disclosed |
| US-20040152133-A1 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | GELLMAN SAMUEL H (US) | 2004-08-05 | — | — | US | disclosed |
| US-6727368-B1 | PYRROLIDINE-3-CARBOXYLIC ACID MONOMERS; POLYLACTAMS; COMBINATORIAL LIBRARIES | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2004-04-27 | — | — | US | disclosed |
| US-6710186-B2 | CONFORMATIONALLY-RESTRICTED; ANALOGOUS TO POLY(PROLINE) II HELICAL STRUCTURE | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2004-03-23 | — | — | US | disclosed |
| US-20030119189-A1 | Method for delivery of molecules to intracellular targets | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-06-26 | — | — | US | disclosed |
| WO-2003024477-A1 | METHOD FOR DELIVERY OF MOLECULES TO INTRACELLULAR TARGETS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2003-03-27 | — | — | WO | disclosed |
| EP-1192136-A2 | OLIGOMERS AND POLYMERS OF CYCLIC IMINO CARBOXYLIC ACIDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2002-04-03 | — | — | EP | disclosed |
| US-20020032334-A1 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2002-03-14 | — | — | US | disclosed |
| WO-2000076974-A2 | OLIGOMERS AND POLYMERS OF CYCLIC IMINO CARBOXYLIC ACIDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2000-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032334-A1 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | PCNA, PAICS, INHA | SMN1; SMN2 1138/4885NPC1 3862/4885RAB9A 3744/4885 |
| US-20040152133-A1 | Oligomers and polymers of di-substituted cyclic imino carboxylic acids | PCNA, PAICS, INHA | SMN1; SMN2 1138/4885NPC1 3862/4885RAB9A 3744/4885 |
| US-20030119189-A1 | Method for delivery of molecules to intracellular targets | DNPEP, SLC7A1, PHAX | SMN1; SMN2 2070/4885NPC1 238/4885RAB9A 1113/4885 |
| US-20130172313-A1 | Carbapenem Antibacterials with Gram-Negative Activity | MGAM, GSK3B, GSK3A | SMN1; SMN2 2268/4885NPC1 1620/4885RAB9A 1220/4885 |
| US-20150306071-A1 | Carbapenem Antibacterials with Gram-Negative Activity | MGAM, GSK3B, GSK3A | SMN1; SMN2 2268/4885NPC1 1620/4885RAB9A 1220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.