Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 4/20 | 0.56 |
| ▸ | CDK9 | P50750 | 4/20 | 0.56 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 5/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.48 |
| ▸ | CHUK | O15111 | 6/20 | 0.48 |
| ▸ | INSR | P06213 | 6/20 | 0.48 |
| ▸ | CAMKK2 | Q96RR4 | 6/20 | 0.48 |
| ▸ | CDC7 | O00311 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1838343 | 0.80 | GSK3B (0.53) | CCNT1CDK9JAK2MAPK8CHUK | |
| SCHEMBL1839153 | 0.79 | MAPK8 (0.49) | CCNT1CDK9NUDT1JAK2MAPK8 | |
| SCHEMBL1841577 | 0.76 | CHUK (0.45) | CCNT1CDK9NUDT1JAK2MAPK8 | |
| SCHEMBL1840513 | 0.76 | GSK3B (0.46) | CCNT1CDK9JAK2CDC7CDK1 | |
| SCHEMBL1718335 | 0.75 | PRKCI (0.71) | CCNT1CDK9NUDT1JAK2MAPK8 | |
| SCHEMBL1840135 | 0.75 | DYRK1A (0.52) | CCNT1CDK9JAK2MAPK8CHUK | |
| SCHEMBL16050477 | 0.72 | CCNT1 (1.00) | CCNT1CDK9 | |
| SCHEMBL30731031 | 0.69 | CDC7 (0.62) | CAMKK2CDC7CDK2GSK3BPRKCI | |
| SCHEMBL5564786 | 0.68 | ROCK1 (0.63) | ROCK2PRKACAROCK1 | |
| SCHEMBL4791550 | 0.68 | PRKCI (0.72) | CDK9NUDT1JAK2MAPK8CHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011526931-A | — | — | 2011-10-20 | — | — | JP | claimed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | claimed |
| EP-2320895-A2 | CDK MODULATORS | Exelixis, Inc. (US) | 2011-05-18 | — | — | EP | claimed |
| WO-2010003133-A2 | CDK MODULATORS | EXELIXIS INC. (US) | 2010-01-07 | — | — | WO | claimed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| WO-2010003133-A2 | CDK MODULATORS | EXELIXIS INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | CDK3, CDK1, CDKL1 | CCNT1 25/4885CDK9 6/4885NUDT1 2054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.