Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26203678 | 0.71 | CHRNA7 (0.41) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL17679889 | 0.71 | HRH3 (0.39) | HRH3KCNH2CYP2D6 | |
| SCHEMBL17618329 | 0.69 | CHRNA7 (0.39) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL26203604 | 0.68 | HRH3 (0.41) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL24127035 | 0.67 | HRH3 (0.40) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL12448088 | 0.67 | HRH3 (0.40) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL24027085 | 0.66 | HRH3 (0.40) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL15946659 | 0.66 | HRH3 (0.46) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL15086036 | 0.65 | HRH3 (0.41) | CHRM1CHRNA7HRH3KCNH2CYP2D6 | |
| SCHEMBL21946657 | 0.65 | DAO (0.35) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763978-B1 | CARBAMATE/ UREA DERIVATIVES CONTAINING PIPERIDIN AND PIPERAZIN RINGS AS H3 RECEPTOR INHIBITORS | NOVARTIS AG (CH) | 2017-02-01 | — | — | EP | disclosed |