Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21336923 | 1.00 | CHRM2 (0.37) | CHRM2HRH4KITJAK1SLC22A12 | |
| SCHEMBL17127783 | 1.00 | CHRM2 (0.37) | CHRM2HRH4KITJAK1SLC22A12 | |
| SCHEMBL18436341 | 1.00 | CHRM2 (0.37) | CHRM2HRH4KITJAK1SLC22A12 | |
| SCHEMBL17128117 | 0.93 | MEN1 (0.38) | CHRM2HRH4JAK1MAPKAPK2TGFBR1 | |
| SCHEMBL18436078 | 0.92 | CHRM2 (0.39) | CHRM2HRH4KITEGLN1 | |
| SCHEMBL17128175 | 0.92 | CHRM2 (0.39) | CHRM2HRH4KITEGLN1 | |
| SCHEMBL17128386 | 0.92 | CHRM2 (0.39) | CHRM2HRH4KITEGLN1 | |
| SCHEMBL18436834 | 0.92 | CHRM2 (0.39) | CHRM2HRH4KITEGLN1 | |
| SCHEMBL17128119 | 0.90 | CHRM2 (0.34) | CHRM2HRH4KITJAK1SLC22A12 | |
| SCHEMBL17128014 | 0.90 | CHRM2 (0.36) | CHRM2HRH4KITJAK1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |