Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 8/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21256819 | 0.82 | SOS1 (0.39) | PRKDCMAP3K12MTORPIK3CASOS1 | |
| SCHEMBL12082429 | 0.82 | SOS1 (0.39) | PRKDCMAP3K12MTORPIK3CASOS1 | |
| SCHEMBL21256815 | 0.82 | SOS1 (0.39) | PRKDCMAP3K12MTORPIK3CASOS1 | |
| SCHEMBL15399039 | 0.82 | MAP3K12 (0.44) | PRKDCMAP3K12MTORPIK3CASOS1 | |
| SCHEMBL25889732 | 0.82 | MAP3K12 (0.39) | PRKDCSYKPDE10AMAP3K12MTOR | |
| SCHEMBL20448663 | 0.82 | MAP3K12 (0.39) | PRKDCSYKPDE10AMAP3K12MTOR | |
| SCHEMBL25889731 | 0.82 | MAP3K12 (0.39) | PRKDCSYKPDE10AMAP3K12MTOR | |
| SCHEMBL23387212 | 0.77 | NSD2 (0.42) | PRKDC | |
| SCHEMBL19221692 | 0.76 | MAPT (0.41) | PRKDC | |
| SCHEMBL23707037 | 0.73 | MAP3K12 (0.43) | MAP3K12MTORPIK3CAMAP3K13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |