Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 3/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.38 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.38 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17128171 | 1.00 | HRH4 (0.40) | HRH4SMOPGRGPR183LRRK2 | |
| SCHEMBL18436454 | 1.00 | HRH4 (0.40) | HRH4SMOPGRGPR183LRRK2 | |
| SCHEMBL17128419 | 1.00 | HRH4 (0.40) | HRH4SMOPGRGPR183LRRK2 | |
| SCHEMBL17127837 | 1.00 | HRH4 (0.40) | HRH4SMOPGRGPR183LRRK2 | |
| SCHEMBL18436945 | 0.96 | HRH4 (0.39) | HRH4SMOPGRGPR183LRRK2 | |
| SCHEMBL17128036 | 0.96 | HRH4 (0.39) | HRH4SMOPGRGPR183LRRK2 | |
| SCHEMBL18436846 | 0.96 | HRH4 (0.39) | HRH4SMOPGRGPR183LRRK2 | |
| SCHEMBL18436345 | 0.96 | HRH4 (0.39) | HRH4SMOPGRGPR183LRRK2 | |
| SCHEMBL18436933 | 0.90 | LRRK2 (0.38) | SMOPGRGPR183LRRK2AOC3 | |
| SCHEMBL17127858 | 0.90 | LRRK2 (0.38) | SMOPGRGPR183LRRK2AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |