Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL128246 | 0.82 | TSHR (0.54) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL2896520 | 0.79 | TSHR (0.50) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL6215006 | 0.79 | TSHR (0.50) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL11524614 | 0.79 | TSHR (0.50) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL5481281 | 0.79 | TSHR (0.50) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL767015 | 0.79 | TSHR (0.50) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL8636456 | 0.79 | TSHR (0.50) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| Isopropyl Alcohol SCHEMBL28680436 | 0.77 | TSHR (0.48) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL130862 | 0.76 | TSHR (0.48) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL30145011 | 0.76 | TSHR (0.52) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320732-A2 | SUBSTITUTED IMIDAZOLE COMBINATIONS | Pfizer Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010020896-A2 | SUBSTITUTED IMIDAZOLE COMBINATIONS | PFIZER INC. (US) | 2010-02-25 | — | — | WO | disclosed |