Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.61 |
| ▸ | ACLY | P53396 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.33 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184448 | 0.85 | BCL2 (0.78) | BCL2ACLYEGFRERBB2HDAC1 | |
| SCHEMBL253035 | 0.81 | BCL2 (0.59) | BCL2ACLYEGFRERBB2MEN1 | |
| SCHEMBL184913 | 0.78 | BCL2 (0.80) | BCL2ACLYEGFRERBB2MEN1 | |
| SCHEMBL184600 | 0.77 | BCL2 (1.00) | BCL2ACLYEGFRERBB2HDAC6 | |
| SCHEMBL184782 | 0.77 | BCL2 (0.77) | BCL2ACLYEGFRERBB2HDAC1 | |
| SCHEMBL184839 | 0.74 | BCL2 (0.84) | BCL2ACLYEGFRERBB2HDAC6 | |
| SCHEMBL185096 | 0.73 | BCL2 (0.79) | BCL2ACLYEGFRERBB2LMNA | |
| SCHEMBL185121 | 0.73 | BCL2 (0.85) | BCL2ACLYEGFRERBB2HDAC6 | |
| SCHEMBL184838 | 0.72 | BCL2 (0.81) | BCL2ACLYEGFRERBB2HDAC6 | |
| SCHEMBL184143 | 0.72 | BCL2 (0.81) | BCL2ACLYEGFRERBB2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297103-B1 | HYDROXYPHENYLSULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-01-04 | — | — | EP | disclosed |