Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 14/20 | 0.77 |
| ▸ | CLK3 | P49761 | 14/20 | 0.77 |
| ▸ | DYRK1A | Q13627 | 14/20 | 0.77 |
| ▸ | ITK | Q08881 | 3/20 | 0.63 |
| ▸ | WNT1 | P04628 | 2/20 | 0.62 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18444620 | 0.93 | CLK2 (0.78) | CLK2CLK3DYRK1AITKWNT1 | |
| SCHEMBL18446680 | 0.93 | CLK2 (0.74) | CLK2CLK3DYRK1AITKWNT1 | |
| SCHEMBL18452396 | 0.90 | CLK2 (0.67) | CLK2CLK3DYRK1AITKWNT1 | |
| SCHEMBL18441313 | 0.89 | CLK2 (0.75) | CLK2CLK3DYRK1AITKWNT1 | |
| SCHEMBL18446715 | 0.88 | CLK2 (0.87) | CLK2CLK3DYRK1AITKWNT1 | |
| SCHEMBL18448101 | 0.87 | CLK2 (0.87) | CLK2CLK3DYRK1AWNT1 | |
| SCHEMBL18448443 | 0.87 | CLK3 (0.87) | CLK2CLK3DYRK1AWNT1 | |
| SCHEMBL18447889 | 0.87 | CLK3 (1.00) | CLK2CLK3DYRK1AWNT1CDK7 | |
| SCHEMBL18442373 | 0.87 | CLK2 (0.71) | CLK2CLK3DYRK1AITKWNT1 | |
| SCHEMBL18486888 | 0.85 | CLK2 (0.86) | CLK2CLK3DYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017024013-A1 | 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC. (US) | 2017-02-09 | — | — | WO | claimed |
| WO-2017024013-A1 | 3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC. (US) | 2017-02-09 | — | — | WO | disclosed |