Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.67 |
| ▸ | PKM | P14618 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | HTR6 | P50406 | 3/20 | 0.66 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1844602 | 0.94 | MAPT (0.75) | MAPTPKMGAACYP1A2CYP3A4 | |
| SCHEMBL1842697 | 0.89 | MAPT (0.82) | MAPTPKMGAACYP1A2CYP3A4 | |
| SCHEMBL1843743 | 0.85 | MAPT (0.77) | MAPTPKMGAACYP1A2CYP3A4 | |
| SCHEMBL1842302 | 0.85 | MAPT (0.74) | MAPTPKMGAACYP1A2CYP3A4 | |
| SCHEMBL1843504 | 0.85 | MAPT (0.74) | MAPTPKMGAACYP1A2CYP3A4 | |
| SCHEMBL1844134 | 0.85 | MAPT (0.80) | MAPTPKMGAACYP1A2CYP3A4 | |
| SCHEMBL1844971 | 0.84 | MAPT (0.70) | MAPTPKMGAACYP1A2CYP3A4 | |
| SCHEMBL1846087 | 0.83 | MAPT (0.73) | MAPTPKMGAACYP1A2CYP3A4 | |
| SCHEMBL1844898 | 0.83 | MAPT (0.72) | MAPTPKMGAACYP1A2CYP3A4 | |
| SCHEMBL1844140 | 0.83 | MAPT (0.76) | MAPTPKMGAACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320897-A1 | COMPOSITIONS AND METHODS OF TREATING AMYLOID DISEASE | Treventis Corporation (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010025375-A1 | COMPOSITIONS AND METHODS OF TREATING AMYLOID DISEASE | TREVENTIS CORPORATION (US) | 2010-03-04 | — | — | WO | disclosed |