Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.62 |
| ▸ | RAB9A | P51151 | 11/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | G6PD | P11413 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | SCD | O00767 | 2/20 | 0.59 |
| ▸ | DHODH | Q02127 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1845273 | 0.91 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2ALDH1A1G6PD | |
| SCHEMBL5836282 | 0.76 | CCNE1 (0.69) | NPC1RAB9ASMN1; SMN2ALDH1A1G6PD | |
| SCHEMBL31065 | 0.74 | SCD (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3591591 | 0.74 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2ALDH1A1G6PD | |
| SCHEMBL4916511 | 0.74 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL1845956 | 0.74 | PIK3CA (0.45) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2876115 | 0.73 | MEN1 (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2752602 | 0.73 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL13156873 | 0.72 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2ALDH1A1G6PD | |
| SCHEMBL16742048 | 0.72 | SCD (0.85) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467969-B1 | DNA MINOR GROOVE BINDING COMPOUNDS | UNIV STRATHCLYDE (GB) | 2011-05-18 | — | — | EP | disclosed |
| US-7700765-B2 | DNA minor groove binding compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2010-04-20 | — | — | US | disclosed |
| US-20070117760-A1 | Dna minor groove binding compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2007-05-24 | — | — | US | disclosed |
| EP-1467969-A2 | DNA MINOR GROOVE BINDING COMPOUNDS | The University of Strathclyde (GB) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003059881-A2 | DNA MINOR GROOVE BINDING COMPOUNDS | UNIVERSITY OF STRATHCLYDE (GB) | 2003-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117760-A1 | Dna minor groove binding compounds | PCNA, POLL, POLM | NPC1 2675/4885RAB9A 4832/4885SMN1; SMN2 4093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.