Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5021232 | 0.88 | LRRK2 (0.73) | LRRK2CYP1A2 | |
| SCHEMBL21613976 | 0.88 | LRRK2 (0.73) | LRRK2CYP1A2 | |
| SCHEMBL9288728 | 0.85 | LRRK2 (1.00) | LRRK2CYP1A2 | |
| SCHEMBL19445973 | 0.84 | LRRK2 (0.67) | LRRK2CYP1A2 | |
| SCHEMBL5021137 | 0.83 | LRRK2 (1.00) | LRRK2CYP1A2 | |
| SCHEMBL4564821 | 0.80 | LRRK2 (0.73) | LRRK2CYP1A2 | |
| SCHEMBL15528495 | 0.79 | LRRK2 (1.00) | LRRK2CYP1A2 | |
| SCHEMBL4561192 | 0.79 | LRRK2 (0.77) | LRRK2CYP1A2 | |
| SCHEMBL4561148 | 0.79 | LRRK2 (0.77) | LRRK2CYP1A2 | |
| SCHEMBL4559344 | 0.79 | LRRK2 (0.74) | LRRK2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638031-B1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH INC (US) | 2017-10-11 | — | — | EP | disclosed |
| EP-3124483-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2017-02-01 | — | — | EP | disclosed |