Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 known ✓ | P30542 | 2/20 | 0.58 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.58 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.58 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | DPP4 | P27487 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.58 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.58 |
| ▸ | GAPDH | P04406 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | STAT6 | P42226 | 1/20 | 0.58 |
| ▸ | PI4KA | P42356 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.58 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.58 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.58 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL18917562 | 0.91 | RXFP1 (0.74) | RXFP1ADORA1SMN1; SMN2DPP4MEN1 | |
| Adenosine SCHEMBL28608116 | 0.90 | ADORA1 (0.70) | ADORA1SMN1; SMN2DPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL31375407 | 0.90 | ADORA1 (0.70) | ADORA1SMN1; SMN2DPP4MEN1SLC28A1 | |
| Adenosine Triphosphate SCHEMBL1948818 | 0.89 | RXFP1 (0.70) | RXFP1KMT2AP2RY1P2RY11TSHR | |
| Adenosine Triphosphate SCHEMBL1948824 | 0.88 | P2RY1 (0.71) | RXFP1SMN1; SMN2P2RY1P2RY11TSHR | |
| Adenosine SCHEMBL8378802 | 0.87 | SMN1; SMN2 (0.68) | ADORA1SMN1; SMN2DPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL3183004 | 0.87 | ADORA1 (0.77) | ADORA1SMN1; SMN2DPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL2442774 | 0.87 | ADORA1 (0.77) | ADORA1SMN1; SMN2DPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL5903597 | 0.86 | ADORA1 (0.75) | ADORA1SMN1; SMN2DPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL3134331 | 0.86 | ADORA1 (0.75) | ADORA1SMN1; SMN2DPP4MEN1SLC28A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321330-B1 | METHOD FOR PRODUCING PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES | UNIVERSITÄT HAMBURG (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2321330-A1 | METHOD FOR PRODUCING PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES | Universität Hamburg (DE) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010015245-A1 | METHOD FOR PRODUCING PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES | UNIVERSITÄT HAMBURG (DE) | 2010-02-11 | — | — | WO | disclosed |