Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.70 |
| ▸ | AURKA | O14965 | 6/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.46 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2483078 | 0.94 | SYK (0.68) | SYKAURKAJAK2NTRK1ROS1 | |
| SCHEMBL2476048 | 0.87 | SYK (0.68) | SYKAURKAJAK2NTRK1ROS1 | |
| SCHEMBL2475525 | 0.86 | SYK (0.69) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2479122 | 0.86 | SYK (0.66) | SYKAURKA | |
| SCHEMBL2478833 | 0.86 | SYK (0.71) | SYKAURKAJAK2NTRK1ROS1 | |
| SCHEMBL2482698 | 0.85 | SYK (0.70) | SYKAURKAJAK2NTRK1ROS1 | |
| SCHEMBL18499156 | 0.82 | SYK (0.79) | SYKAURKA | |
| SCHEMBL2480245 | 0.82 | SYK (1.00) | SYK | |
| SCHEMBL2898376 | 0.82 | SYK (0.69) | SYKAURKA | |
| SCHEMBL2480712 | 0.81 | SYK (0.83) | SYKAURKAJAK2NTRK1ROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3123864-A1 | IMIDAZOPYRAZINE SYK INHIBITORS | Gilead Connecticut, Inc. (US) | 2017-02-01 | — | — | EP | disclosed |