Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.74 |
| ▸ | INSR | P06213 | 18/20 | 0.74 |
| ▸ | NPM1 | P06748 | 10/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | ABL1 | P00519 | 1/20 | 0.70 |
| ▸ | EGFR | P00533 | 1/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.70 |
| ▸ | LCK | P06239 | 1/20 | 0.70 |
| ▸ | RET | P07949 | 1/20 | 0.70 |
| ▸ | IGF1R | P08069 | 1/20 | 0.70 |
| ▸ | MET | P08581 | 1/20 | 0.70 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.70 |
| ▸ | CDK2 | P24941 | 1/20 | 0.70 |
| ▸ | AKT1 | P31749 | 1/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.70 |
| ▸ | GSK3B | P49841 | 1/20 | 0.70 |
| ▸ | PLK1 | P53350 | 1/20 | 0.70 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.70 |
| ▸ | BTK | Q06187 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3958863 | 0.90 | ALK (0.78) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL21183052 | 0.86 | ALK (0.55) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL1949915 | 0.86 | ALK (0.81) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL1546090 | 0.85 | ALK (1.00) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL1546085 | 0.85 | ALK (1.00) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL21539062 | 0.85 | ALK (0.54) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL12213956 | 0.83 | ALK (1.00) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL1950314 | 0.83 | ALK (1.00) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL21099671 | 0.83 | ALK (0.80) | ALKINSRNPM1KCNH2CYP3A4 | |
| SCHEMBL1952646 | 0.83 | ALK (1.00) | ALKINSRNPM1KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3560959-B1 | ANTIBODY MOLECULES TO TIM-3 AND USES THEREOF | NOVARTIS AG (CH) | 2023-11-22 | — | — | EP | disclosed |
| EP-3878465-A1 | COMBINATION THERAPIES COMPRISING ANTIBODY MOLECULES TO TIM-3 | Novartis AG (CH) | 2021-09-15 | — | — | EP | disclosed |
| WO-2020236792-A1 | CD19 BINDING MOLECULES AND USES THEREOF | NOVARTIS AG (CH) | 2020-11-26 | — | — | WO | disclosed |
| EP-3660050-A1 | ANTIBODY MOLECULES TO LAG-3 AND USES THEREOF | Novartis AG (CH) | 2020-06-03 | — | — | EP | disclosed |
| EP-3116909-B1 | ANTIBODY MOLECULES TO LAG-3 AND USES THEREOF | NOVARTIS AG (CH) | 2019-11-13 | — | — | EP | disclosed |
| EP-3560959-A1 | ANTIBODY MOLECULES TO TIM-3 AND USES THEREOF | Novartis AG (CH) | 2019-10-30 | — | — | EP | disclosed |
| EP-3514179-A1 | ANTIBODY MOLECULES TO PD-1 AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| EP-3099717-B1 | ANTIBODY MOLECULES TO TIM-3 AND USES THEREOF | NOVARTIS AG (CH) | 2019-03-27 | — | — | EP | disclosed |
| WO-2019018640-A1 | DOSAGE REGIMENS FOR ANTI-GITR ANTIBODIES AND USES THEREOF | NOVARTIS AG (CH) | 2019-01-24 | — | — | WO | disclosed |
| WO-2017106656-A1 | ANTIBODY MOLECULES TO PD-1 AND USES THEREOF | NOVARTIS AG (CH) | 2017-06-22 | — | — | WO | disclosed |
| WO-2017075477-A1 | COMPOSITIONS AND METHODS FOR ACTIVATING \"STIMULATOR OF INTERFERON GENE\"-DEPENDENT SIGNALLING | Aduro Biotech, Inc. (US) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017019897-A1 | COMBINATION THERAPIES COMPRISING ANTIBODY MOLECULES TO TIM-3 | NOVARTIS AG (CH) | 2017-02-02 | — | — | WO | disclosed |