Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.46 |
| ▸ | RAF1 | P04049 | 13/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5575760 | 0.84 | MAPK14 (0.61) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL668648 | 0.81 | MAPK14 (0.61) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL1396018 | 0.81 | RAF1 (0.63) | MAPK14RAF1MAPK13 | |
| SCHEMBL1846138 | 0.79 | MAPK14 (0.49) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL668382 | 0.79 | RAF1 (0.62) | MAPK14RAF1MAPK13 | |
| SCHEMBL1846789 | 0.79 | RAF1 (0.71) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL1846781 | 0.78 | RAF1 (0.63) | MAPK14RAF1MAPK13MAPK12MAPK11 | |
| SCHEMBL667815 | 0.77 | RAF1 (0.60) | MAPK14RAF1MAPK13 | |
| SCHEMBL939302 | 0.75 | MAPK14 (0.49) | MAPK14RAF1MAPK13 | |
| SCHEMBL2083949 | 0.74 | GRM5 (0.48) | MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324825-A1 | Aryl ureas with angiogenesis inhibiting activity | Bayer Healthcare LLC (US) | 2011-05-25 | — | — | EP | claimed |
| EP-2324825-A1 | Aryl ureas with angiogenesis inhibiting activity | Bayer Healthcare LLC (US) | 2011-05-25 | — | — | EP | disclosed |