Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31298939 | 0.81 | GAA (0.50) | GAAMAPTPOLBHPGDHTR2A | |
| SCHEMBL10389943 | 0.80 | TDP1 (0.43) | TYRMAPTHTR2AKDM4EKMT2A | |
| SCHEMBL16109310 | 0.80 | GAA (0.49) | GAAMAPTPOLBHPGDHTR2A | |
| SCHEMBL10492576 | 0.79 | TYR (0.48) | TYRKDM4EKMT2ALMNAALDH1A1 | |
| SCHEMBL25061971 | 0.79 | HPGD (0.56) | TYRMAPTPOLBHPGDGLA | |
| SCHEMBL31016246 | 0.79 | GAA (0.51) | GAAMAPTPOLBHPGDHTR2A | |
| SCHEMBL31016247 | 0.79 | GAA (0.51) | GAAMAPTPOLBHPGDHTR2A | |
| SCHEMBL16108505 | 0.79 | GAA (0.51) | GAAMAPTPOLBHPGDHTR2A | |
| SCHEMBL16108662 | 0.78 | GAA (0.58) | GAAMAPTPOLBHPGDHTR2A | |
| SCHEMBL10907895 | 0.77 | TYR (0.46) | TYRMAPTKDM4EKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2978758-B1 | DIHYDROQUINAZOLINONE ANALOGUES AS BRD4 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2017-02-08 | — | — | EP | disclosed |