Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 7/20 | 0.70 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.52 |
| ▸ | INSR | P06213 | 3/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15938745 | 0.83 | MAPK3 (1.00) | MAPK3 | |
| SCHEMBL15937918 | 0.79 | MAPK3 (1.00) | MAPK3 | |
| SCHEMBL19846669 | 0.78 | EGFR (0.56) | MAPK3ALKINSRIGF1RLRRK2 | |
| SCHEMBL1707144 | 0.76 | MAPK3 (0.62) | MAPK3ALKLRRK2 | |
| SCHEMBL9911252 | 0.76 | MAPK3 (0.62) | MAPK3LRRK2 | |
| SCHEMBL19846664 | 0.75 | ALK (0.72) | ALKINSRIGF1R | |
| SCHEMBL12312032 | 0.74 | MAPK3 (0.60) | MAPK3ALKINSRIGF1RLRRK2 | |
| SCHEMBL12311880 | 0.74 | MAPK3 (0.64) | MAPK3ALKINSRIGF1RLRRK2 | |
| SCHEMBL12337109 | 0.72 | MAPK3 (0.60) | MAPK3ALKINSRIGF1RLRRK2 | |
| SCHEMBL1707303 | 0.72 | MAPK3 (0.56) | MAPK3ALKINSRLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9561228-B2 | ERK inhibitors and uses thereof | CELGENE AVILOMICS RESEARCH, INC. (US) | 2017-02-07 | — | — | US | disclosed |