Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14998247 | 0.92 | CYP1A2 (0.38) | BACE1KCNH2CYP1A2CLK4CYP3A4 | |
| SCHEMBL12288163 | 0.92 | CYP1A2 (0.38) | BACE1KCNH2CYP1A2CLK4CYP3A4 | |
| SCHEMBL2562022 | 0.92 | CYP1A2 (0.38) | BACE1KCNH2CYP1A2CLK4CYP3A4 | |
| SCHEMBL2562049 | 0.81 | KCNH2 (0.39) | BACE1KCNH2 | |
| SCHEMBL14998419 | 0.81 | KCNH2 (0.39) | BACE1KCNH2 | |
| SCHEMBL2564101 | 0.80 | KCNH2 (0.38) | KCNH2CYP3A4CYP2D6 | |
| SCHEMBL15002825 | 0.80 | KCNH2 (0.38) | KCNH2CYP3A4CYP2D6 | |
| SCHEMBL14998238 | 0.80 | KCNH2 (0.38) | KCNH2CYP3A4CYP2D6 | |
| SCHEMBL14998274 | 0.77 | KCNH2 (0.41) | KCNH2DPP4 | |
| SCHEMBL16524112 | 0.77 | KCNH2 (0.41) | KCNH2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |
| EP-3127541-A1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | Cytokinetics, Inc. (US) | 2017-02-08 | — | — | EP | disclosed |