Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 14/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1846785 | 0.84 | RAF1 (0.64) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1846665 | 0.82 | RAF1 (0.62) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8737812 | 0.80 | RAF1 (0.69) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1847101 | 0.79 | RAF1 (0.60) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8736853 | 0.78 | RAF1 (0.66) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8737814 | 0.78 | RAF1 (0.67) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14402931 | 0.76 | RAF1 (0.68) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1846663 | 0.76 | RAF1 (0.61) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1846781 | 0.76 | RAF1 (0.63) | RAF1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL938435 | 0.76 | RAF1 (1.00) | RAF1MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324825-A1 | Aryl ureas with angiogenesis inhibiting activity | Bayer Healthcare LLC (US) | 2011-05-25 | — | — | EP | disclosed |