Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 3/20 | 0.50 |
| ▸ | HTR1D | P28221 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | GABRP | O00591 | 1/20 | 0.48 |
| ▸ | GABRD | O14764 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3832948 | 0.86 | HTR2C (0.62) | IDO1HTR1BHTR1DCYP1A2CYP3A4 | |
| SCHEMBL8096608 | 0.86 | HTR1D (0.53) | IDO1HTR1BHTR1DCYP1A2CYP3A4 | |
| SCHEMBL12367411 | 0.85 | IDO1 (0.54) | IDO1HTR1BHTR1DAPPADRB2 | |
| Hydrochloric Acid SCHEMBL30375480 | 0.84 | HTR2C (0.63) | IDO1HTR1BHTR1DCYP1A2CYP3A4 | |
| SCHEMBL4674841 | 0.84 | IDO1 (0.50) | IDO1HTR1BHTR1DCYP1A2CYP3A4 | |
| SCHEMBL23010847 | 0.83 | HTR1D (0.72) | HTR1BHTR1DCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL18441017 | 0.83 | SLC6A4 (0.56) | IDO1HTR1BHTR1DHTR2CSLC6A4 | |
| SCHEMBL18474204 | 0.83 | SLC6A4 (0.56) | IDO1HTR1BHTR1DHTR2CSLC6A4 | |
| SCHEMBL13849957 | 0.82 | IDO1 (0.54) | IDO1HTR1BHTR1DCYP1A2CYP3A4 | |
| SCHEMBL18622640 | 0.81 | CYP1A2 (0.69) | HTR1BHTR1DCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017023894-A1 | MTHFD2 INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-02-09 | — | — | WO | disclosed |