Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 8/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | PTGFR | P43088 | 1/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1847632 | 0.84 | PTGER4 (0.66) | PTGER4PTGDRPTGER2PTGER3 | |
| SCHEMBL1954049 | 0.84 | PTGER4 (0.66) | PTGER4PTGDRPTGER2PTGER3 | |
| SCHEMBL1842802 | 0.83 | PTGER4 (0.43) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| SCHEMBL1844421 | 0.82 | PTGER4 (0.48) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| SCHEMBL196448 | 0.82 | PTGER4 (0.67) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| Diethanolamine SCHEMBL28521337 | 0.79 | PTGER4 (0.60) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| Tromethamine SCHEMBL22633156 | 0.79 | PTGER4 (0.62) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| SCHEMBL16524288 | 0.79 | PTGER4 (0.69) | PTGER4PTGER2MAPTPPARA | |
| SCHEMBL1845684 | 0.78 | KDM4E (0.44) | PTGER4PTGDRPTGER2TBXA2RPTGER1 | |
| SCHEMBL32684475 | 0.74 | PTGER4 (0.43) | PTGER4PTGDRPTGER2TBXA2RPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320906-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | Beta Pharma Canada Inc. (CA) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010019796-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | CHEMIETEK, LLC (US) | 2010-02-18 | — | — | WO | disclosed |