Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1853199 | 0.93 | SYK (0.74) | SYK | |
| SCHEMBL1354293 | 0.89 | SYK (1.00) | SYK | |
| SCHEMBL1354298 | 0.89 | SYK (1.00) | SYK | |
| SCHEMBL1852111 | 0.82 | SYK (0.61) | SYK | |
| SCHEMBL1846929 | 0.81 | SYK (0.77) | SYK | |
| SCHEMBL1353997 | 0.80 | SYK (1.00) | SYK | |
| SCHEMBL1353903 | 0.80 | SYK (1.00) | SYK | |
| SCHEMBL1354000 | 0.80 | SYK (1.00) | SYK | |
| SCHEMBL1353901 | 0.80 | SYK (1.00) | SYK | |
| SCHEMBL1847949 | 0.80 | SYK (0.86) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323993-A2 | 2,6-DIAMINO- PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2009136995-A2 | INHIBITORS OF SYK PROTEIN KINASE | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |