Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 17/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735912 | 0.86 | HRH4 (0.71) | HRH4HRH3 | |
| SCHEMBL603693 | 0.84 | HRH4 (1.00) | HRH4KDM4EMAPTRECQLNPSR1 | |
| SCHEMBL603973 | 0.82 | HRH4 (0.69) | HRH4KDM4EMAPTKMT2ALMNA | |
| SCHEMBL604823 | 0.78 | HRH4 (0.74) | HRH4MAPTNPSR1HRH3MEN1 | |
| SCHEMBL2166354 | 0.78 | HRH4 (0.74) | HRH4MAPTNPSR1HRH3MEN1 | |
| SCHEMBL2166543 | 0.78 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL2166541 | 0.78 | HRH4 (1.00) | HRH4HRH3 | |
| SCHEMBL14565235 | 0.76 | HRH4 (0.85) | HRH4HRH3 | |
| SCHEMBL4594250 | 0.75 | HRH4 (0.65) | HRH4KDM4EMAPTHRH3 | |
| SCHEMBL4594254 | 0.75 | HRH4 (0.65) | HRH4KDM4EMAPTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3130376-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2017-02-15 | — | — | EP | disclosed |