SCHEMBL18486972

SCHEMBL18486972

CNCCCNc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(CC4=C(c5ccc(Cl)cc5)CC(C)(C)CC4)CC3)cc2Oc2ccccc2F)cc1[N+](=O)[O-]

nearest known ligand 0.88

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ BCL2 P10415 19/20 0.88

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1959736 0.94 BCL2 (1.00) BCL2
SCHEMBL1954936 0.93 BCL2 (1.00) BCL2
SCHEMBL1957299 0.92 BCL2 (1.00) BCL2
SCHEMBL1960374 0.89 BCL2 (1.00) BCL2
SCHEMBL1956455 0.89 BCL2 (1.00) BCL2
SCHEMBL1957554 0.88 BCL2 (1.00) BCL2
SCHEMBL1956371 0.88 BCL2 (0.92) BCL2
SCHEMBL1959117 0.88 BCL2 (1.00) BCL2
SCHEMBL1957663 0.88 BCL2 (1.00) BCL2
SCHEMBL1960599 0.87 BCL2 (1.00) BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2376197-B1 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABBVIE INC (US) 2017-02-15 — — EP claimed
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