Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.35 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7791030 | 0.73 | FLT1 (0.55) | PTK2AURKAFGFR1FGFR4FGFR3 | |
| SCHEMBL1847410 | 0.72 | BRAF (0.51) | AURKANPC1RAB9ASMN1; SMN2SYK | |
| SCHEMBL1868898 | 0.66 | BRAF (0.45) | PTK2AURKAFGFR1FGFR3MAPK8 | |
| SCHEMBL29398215 | 0.66 | PTK2 (0.48) | PTK2AURKACCNCCDK8NPC1 | |
| SCHEMBL17110620 | 0.65 | POLB (0.56) | PTK2AURKARAD52NPC1RAB9A | |
| SCHEMBL7799235 | 0.64 | CSF1R (0.52) | AURKAFGFR1FGFR4SMN1; SMN2SYK | |
| SCHEMBL22191517 | 0.63 | PTK2 (0.46) | PTK2AURKACCNCCDK8NPC1 | |
| SCHEMBL1866091 | 0.62 | RPS6KB1 (0.38) | RPS6KB1 | |
| SCHEMBL6851890 | 0.62 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3951907 | 0.62 | AURKA (0.56) | PTK2AURKACCNCCDK8NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323986-A2 | HETOEROCYCLYL CARBONIC ACID AMIDES AS ANTIPROLIFERATIVE AGENTS, PDKL INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2011-05-25 | — | — | EP | disclosed |